Week 5 NFL Odds: Spread, Moneyline, and Total for All Games

• The NFL Week 5 spreads, moneyline, and totals have been posted
• The Chargers, Eagles, Lions, and Titans are on byes in Week 5
• Below, see the opening NFL Week 5 odds for all 14 games on the schedule

The NFL Week 5 odds have been released, starting with the Tampa Bay Buccaneers (3-1) vs Atlanta Falcons (2-2) on Thursday and culminating with the New Orleans Saints (2-2) vs Kansas City Chiefs (4-0) on Monday Night Football.

Four teams – the LA Chargers, Philadelphia Eagles, Detroit Lions, and Tennessee Titans – are on their bye week, so the Week 5 slate only includes 14 games. The table below shows the opening NFL Week 5 lines – including spread, moneyline, and game total – for all 14 games.

Opening NFL Week 5 Odds

In keeping with the parity we’re seeing in the league as a whole this season, the Week 5 NFL odds include nine spreads that are a field goal or lower. Only one of the 14 games has a point spread is over a touchdown.

Odds as of Sep. 29 at FanDuel and DraftKings. Claim the DraftKings promo code to bet on NFL Week 5. 

Biggest Week 5 Spread: Cardinals at 49ers (-7.5)

The biggest spread of Week 5 comes from the Arizona Cardinals (1-3) vs San Francisco 49ers (2-2), where the Niners are laying 7.5 points at home.

Despite a boatload of injuries, especially on the offensive side of the ball, the 49ers ran over the Patriots 30-13 at home in Week 4, easily covering as 10.5-point chalk. The Niners remain second only to the two-time defending champion Kansas City Chiefs in the Super Bowl 59 odds.

The Cardinals, meanwhile, lost their second straight game – and fell to 1-3 overall – thanks to a dismal 42-14 loss at home to the Commanders as 3.5-point home favorites.

Highest Week 5 Game Total: Cardinals vs 49ers (49.5 O/U)

The Arizona vs San Francisco matchup also has the distinction of the highest Week 5 game total at 49.5, which is one point higher than the huge AFC North matchup between the Baltimore Ravens (1-2) and Cincinnati Bengals (1-3), who finally picked up their first win of the season at the Panthers (34-24) in Week 4.

OH MY JA’MARR CHASE. ELECTRIC 63-YARD TD.

📺: #CINvsCAR on FOX
📱: https://t.co/waVpO909ge pic.twitter.com/KwYspR7roj

— NFL (@NFL) September 29, 2024

The Bengals (3-1 over/under) may prove to be an over machine this year. Joe Burrow and Ja’Marr Chase have looked as potent as ever the last two weeks (Chase has 203 receiving yards and three touchdowns in the last two games) but the Bengal defense has been porous, and the banged-up unit doesn’t figure to turn a corner until the interior of their line gets healthy.

Lowest Week 5 Game Total: Dolphins vs Patriots (36.5 O/U)

The honor of lowest game total in Week 5 is actually split between two games: both the Miami Dolphins (1-3) vs New England Patriots (1-3) and Las Vegas Raiders (1-3) vs Denver Broncos (2-2) have totals of just 36.5 points. But the Miami/New England total has -110 odds both ways, while the LV/Denver total slightly favors the over at -115.

Miami has yet to play this week, but could only muster 13 total points the last two weeks combined. Starting QB Tua Tagovailoa has missed the bulk of that time and doesn’t figure to return in Week 5.

Heading into Week 4, the NFL over under trends showed Miami as one of just four teams that still hadn’t hit an over this season. (The Chargers, Giants, and Lions were the other three.)

New England, meanwhile, has scored just 16 points in its last two games: a 24-3 loss at the Jets and a 30-13 setback at the 49ers.

Stay tuned to the NFL public betting percentages splits during the week to see where the money is going and how the lines are shifting.

As we head into Week 5 of the NFL season, there are several intriguing matchups on the schedule that have caught the attention of bettors and fans alike. Let’s take a look at the odds for each game, including the spread, moneyline, and total.

First up, we have the Thursday night game between the Los Angeles Rams and the Seattle Seahawks. The Rams are currently favored by 2.5 points, with a moneyline of -140. The total for this game is set at 54.5 points.

On Sunday, the early games feature the New York Jets taking on the Atlanta Falcons. The Falcons are favored by 3.5 points, with a moneyline of -180. The total for this game is 46.5 points.

In another early game, the Green Bay Packers will face off against the Cincinnati Bengals. The Packers are favored by 3 points, with a moneyline of -150. The total for this game is 50.5 points.

In the late afternoon games, the Kansas City Chiefs will take on the Buffalo Bills. The Chiefs are favored by 2.5 points, with a moneyline of -130. The total for this game is 56.5 points.

Finally, the Sunday night game features the San Francisco 49ers against the Arizona Cardinals. The Cardinals are favored by 4.5 points, with a moneyline of -220. The total for this game is 50.5 points.

Overall, Week 5 of the NFL season promises to be an exciting one with plenty of close matchups and high-scoring games. Whether you’re looking to bet on the spread, moneyline, or total, there are plenty of opportunities to make some money this week. So grab your snacks, settle in on the couch, and get ready for some thrilling football action!