Week 5 College Football: Predictions, Picks, and Lines for Kentucky vs Ole Miss

  • Kentucky battles Ole Miss in an all-SEC showdown
  • The Rebels enter as heavy 17.5-point favorites
  • Check out the Kentucky vs Ole Miss odds & predictions

Ole Miss takes on Kentucky in a classic SEC battle on Saturday, September 28 from Vaunt Hemingway Stadium in Oxford, Mississippi. The Rebels will aim to continue their scorching hot start as they begin conference play in this CFB Week 5 clash.

Dive into all the Kentucky vs Ole Miss Week 5 picks, predictions and our best bets below.

Kentucky vs Ole Miss Odds

Team Spread Moneyline Total
Kentucky +17.5 (-110) +540 Over 52.5 (-115)
Ole Miss -17.5(-110) -800 Under 52.5 (-105)

#6 Ole Miss enters Week 5 as a 17.5-point favorite in the latest college football odds. The Kentucky vs Ole Miss total currently sits at 52.5.

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Odds as of September 24th at DraftKings Sportsbook. Browse the best College Football Betting Apps for Kentucky vs Ole Miss.

Kentucky Are No Pushovers

These ain’t your dad’s Kentucky Wildcats. Once only a power in basketball, Kentucky is a very competitive football team under head coach Mark Stoops.

The Wildcats have sandwiched blowout wins over Southern Mississippi and Ohio with losses to South Carolina and Georgia respectively. Kentucky actually had Kirby Smart’s Bulldogs on the ropes late in the fourth quarter, and very nearly handed Georgia their first regular season loss since 2020.

Kentucky’s defense has held opponents to only 12.5 points and 217 offensive yards per contest through four weeks. They’ve also racked up five sacks and 23 hurries. Defensive tackle Deone Walker is a behemoth in the middle of their line. The 6’6, 345-pounder is an immovable object who’s presence can change the game. Ole Miss will be aware of where number 0 is on every snap of the football.

Keep in mind, the college football betting trends don’t favor the Wildcats on Saturday. Kentucky has won just one of their last five meetings against a team with a top-25 scoring defense.

Ole Miss Out to Make the CFB Playoff

Lane Kiffen’s squad are one of the top teams’ in the nation. The Rebels defense is a huge part of that. Ole Miss have allowed just 7.3 yards per game (3rd in the nation), 3.6 yards per play (5th). They’ve held opponents to score on only 50% of red zone opportunities which ranks second in the FBS, and have forced eight turnovers already.

Ole Miss also sports the top overall PFF team grade in the nation at 98.4. They’re also lead the FBS in run defense grade (97), passing grade (92.8), defensive grade (93), and pass rushing grade (89). Kiffen’s beautifully orchestrated offense tops the FBS in yards per game (637.3) and have scored 48 points a night so far.

Quarterback Jaxson Dart has been electric in 2024, tossing for 1554 yards and 12 touchdowns with a 79.8 completion percentage. That being said, those statistics have come against Furman, Middle Tennessee State, Wake Forest, and Georgia Southern. Kentucky will be the first real test for the Rebels this season.

On top of all that stats, Kiffen is on quite the hot streak at home, going 6-2-1 ATS in their last nine home contests.

Kentucky vs Ole Miss Picks

Backing Kentucky’s menacing defensive line as a three-possession underdog would be an easy play, but their offense has been less than stellar this season. Georgia transfer Brock Vandagriff has completed under 60% of his passes at only seven yards per attempt with just three touchdowns and two interceptions.

That being said, moving the football against Ole Miss’ front seven won’t be an easy task. For that reason, the Kentucky vs Ole Miss under 52.5 is the play for this Week 5 SEC showdown.

  • Kentucky vs Ole Miss Pick: Under 52.5 Total Points (-105)

Week 5 of college football is shaping up to be an exciting one, with several marquee matchups on the schedule. One game that is sure to draw plenty of attention is the showdown between the Kentucky Wildcats and the Ole Miss Rebels.

Both teams have had solid starts to the season, with Kentucky boasting a 3-1 record and Ole Miss sitting at 2-2. This game will be crucial for both teams as they look to stay in the hunt for a conference championship.

When it comes to predictions for this game, it’s shaping up to be a close one. Kentucky has been impressive on both sides of the ball, with a strong defense and a balanced offense led by quarterback Will Levis. Ole Miss, on the other hand, has one of the most explosive offenses in the country, led by quarterback Matt Corral.

In terms of picks, this game could really go either way. Kentucky has the advantage on defense, while Ole Miss has the edge on offense. It will likely come down to which team can make the most plays and limit mistakes.

As for the betting lines, Kentucky is currently favored by a slim margin. The over/under for total points scored in the game is set at 60.5, indicating that oddsmakers are expecting a high-scoring affair.

Overall, this game has all the makings of a classic college football showdown. Fans can expect a hard-fought battle between two talented teams, with plenty of excitement and drama along the way. Be sure to tune in to see who comes out on top in this Week 5 matchup between Kentucky and Ole Miss.