Week 4 College Football Odds, Spreads, and Early Predictions for Opening Games

Week 4 College Football Odds, Spreads, and Early Predictions for Opening Games
Memphis Tigers defensive back Harold Stubbs IV recovers a fumble against Florida State

Sep 14, 2024; Tallahassee, Florida, USA; Memphis Tigers defensive back Harold Stubbs IV (42) recovers a fumbled punt return by Florida State Seminoles wide receiver Lawayne McCoy (15) during the first half at Doak S. Campbell Stadium. Mandatory Credit: Melina Myers-Imagn Images

  • Heavyweight matchups between #7 Tennessee vs #13 Oklahoma and #11 USC vs #17 Michigan highlight the Week 4 NCAAF schedule
  •  Winless Florida State is favored for the third straight game, this time at home against 3-0 Cal
  • Below, see the opening college football Week 4 odds, including spread, moneyline, and total, plus my favorite early NCAAF Week 4 picks

The 2024 college football schedule really starts to heat up in Week 4 when fans are treated to three ranked-on-ranked matchups, including a pivotal Big Ten clash between USC and Michigan.

An appetizer of sorts for Week 5, when Georgia and Alabama meet in Tuscaloosa on Sep. 28, Week 4 is sure to have far-reaching impacts on the early College Football Playoff odds.

The table below lists the opening Week 4 NCAAF odds for all games on the board so far. More will be added as they become available. Under the table, find my favorite early Week 4 college football picks, which look to build on a near-perfect 7-1 start to the season (+5.71 units).

Opening College Football Week 4 Odds

Team Spread Moneyline Total Date/Time
South Alabama +7.5 (-110) +198 O 62.5 (-110) Thursday, Sep.19
App State -7.5 (-110) -245 U 62.5 (-110) 7:30  pm ET
Team Spread Moneyline Total Date/Time
Stanford +8.5 (-110) +255 O 57.5 (-110) Friday, Sep.20
Syracuse -8.5 (-110) -320 U 57.5 (-110)  7:30 pm ET
Team Spread Moneyline Total Date/Time
Illinois +8.5 (-110) +260 O 46.5 (-110) Friday, Sep.20
Nebraska -8.5 (-110) -330 U 46.5 (-110)  10 pm ET
Team Spread Moneyline Total Date/Time
San Jose State +13.5 (-110) +360 O 56.5 (-110) Saturday, Sep.21
Washington State -13.5 (-110) -480 U 56.5 (-110) 12 pm ET
Team Spread Moneyline Total Date/Time
Houston +6.5 (-110) +198 O 48.5 (-110) Saturday, Sep.21
Cincinnati -6.5 (-110) -245 U 48.5 (-110) 12 pm ET
Team Spread Moneyline Total Date/Time
Florida -7.5 (-110) -245 O 57.5 (-110) Saturday, Sep.21
Mississippi State +7.5 (-110) +198 U 57.5 (-110) 12 pm ET
Team Spread Moneyline Total Date/Time
Kansas +2.5 (-110) +112 O 58.5 (-110) Saturday, Sep.21
West Virginia -2.5 (-110) -134 U 58.5 (-110) 12 pm ET
Team Spread Moneyline Total Date/Time
NC State +15.5 (-110) +500 O 48.5 (-110) Saturday, Sep.21
Clemson -15.5 (-110) -720 U 48.5 (-110) 12 pm ET
Team Spread Moneyline Total Date/Time
Arkansas State +3.5 (-110) +118 O 50.5 (-110) Saturday, Sep.21
Iowa State -3.5 (-110) -142 U 50.5 (-110) 2 pm ET
Team Spread Moneyline Total Date/Time
Arizona State +3.5 (-110) +118 O 60.5 (-110) Saturday, Sep.21
Texas Tech -3.5 (-110) -142 U 60.5 (-110) 3:30 pm ET
Team Spread Moneyline Total Date/Time
USC -6.5 (-110) -225 O 47.5 (-110) Saturday, Sep.21
Michigan +6.5 (-110) +184 U 47.5 (-110) 3:30 pm ET
Team Spread Moneyline Total Date/Time
Vanderbilt +21.5 (-110) +1000 O 52.5 (-110) Saturday, Sep.21
Missouri -21.5 (-110) -2100 U 52.5 (-110) 3:30 pm ET
Team Spread Moneyline Total Date/Time
Georgia Tech +11.5 (-110) +285 O 57.5 (-110) Saturday, Sep.21
Louisville -11.5 (-110) -365 U 57.5 (-110) 3:30 pm ET
Team Spread Moneyline Total Date/Time
UCLA +23.5 (-110) +1160 O 56.5 (-110) Saturday, Sep.21
LSU -23.5 (-110) -2800 U 56.5 (-110) 3:30 pm ET
Team Spread Moneyline Total Date/Time
Arkansas +5.5 (-110) +160 O 58.5 (-110) Saturday, Sep.21
Auburn -5.5 (-110) -194 U 58.5 (-110) 3:30 pm ET
Team Spread Moneyline Total Date/Time
Utah +2.5 (-110) +108 O 53.5 (-110) Saturday, Sep.21
OK State -2.5 (-110) -130 U 53.5 (-110) 4 pm ET
Team Spread Moneyline Total Date/Time
TCU -2.5 (-110) -142 O 58.5 (-110) Saturday, Sep.21
SMU +2.5 (-110) +118 U 58.5 (-110) 5 pm ET
Team Spread Moneyline Total Date/Time
Cal +3.5 (-110) +132 O 46.5 (-110) Saturday, Sep.21
Florida State -3.5 (-110) -160 U 46.5 (-110) 7 pm ET
Team Spread Moneyline Total Date/Time
Northwestern +9.5 (-110) +270 O 43.5 (-110) Saturday, Sep.21
Washington -9.5 (-110) -345 U 43.5 (-110) 7 pm ET
Team Spread Moneyline Total Date/Time
Tennessee -7.5 (-110) -245 O 58.5 (-110) Saturday, Sep.21
Oklahoma +7.5 (-110) +198 U 58.5 (-110) 7:30  pm ET
Team Spread Moneyline Total Date/Time
Iowa -2.5 (-110) -132 O 37.5 (-110) Saturday, Sep.21
Minnesota +2.5 (-110) +110 U 37.5 (-110) 7:30 pm ET
Team Spread Moneyline Total Date/Time
Michigan State +7.5 (-110) +205 O 45.5 (-110) Saturday, Sep.21
Boston College -7.5 (-110) -255 U 45.5 (-110) 8 pm ET
Team Spread Moneyline Total Date/Time
Baylor -1.5 (-110) -114 O 54.5 (-110) Saturday, Sep.21
Colorado +1.5 (-110) -105 U 54.5 (-110) 8 pm ET
Team Spread Moneyline Total Date/Time
Purdue +4.5 (-110) +158 O 46.5 (-110) Saturday, Sep.21
Oregon State -4.5 (-110) -192 U 46.5 (-110)  8:30 pm ET
Team Spread Moneyline Total Date/Time
Kansas State -7.5 (-110) -310 O 50.5 (-110) Saturday, Sep.21
BYU +7.5 (-110) +240 U 50.5 (-110) 10:30 pm ET

The biggest spread on the board so far is LSU laying 23.5 points at home to UCLA. One game – Baylor vs Colorado – is a virtual pick’em, with the Bears at -114 on the moneyline and the Buffs ever-so-slight -105 home underdogs.

Odds as of Sep. 15 at FanDuel. Get a big FanDuel sign up bonus to bet on NCAAF Week 4. 

In a bit of a rarity for college football, only two of the 25 game totals on the board so far are over 60: South Alabama vs App State, the first game of the week on Thursday, has the highest total at 62.5, while Arizona State vs Texas Tech is at 60.5.

The national championship odds continue to favor Georgia (+280), Ohio State (+400), and Texas (+750), who have all survived the early weeks unscathed.

Meanwhile, Miami QB Cam Ward has taken over as the betting favorite in the 2024 Heisman odds.

Early NCAAF Week 4 Picks

  • Pick #1: Cal moneyline vs Florida State (+132)

I have faded the Seminoles each of the last two weeks and will continue to do so until they so something, literally anything, on the field. They have been outclassed in their three losses to Georgia Tech (24-21 neutral), Boston College (28-13 home), and Memphis (20-12 home). DJ Uiagalelei bears no resemblance to a competent starting QB.

YouTube video

Cal, meanwhile, is 3-0 including a 21-14 road win at Auburn as 11.5-point road underdogs. Auburn is a much better football team than FSU.

I don’t expect the Seminoles to go winless but I still love the value on Cal at +132.

  • Pick #2: Arizona State moneyline (+118) vs Texas Tech

My second pick this week is another SU upset: Arizona State to win on the road in Lubbock against Texas Tech as +118 underdogs.

The Red Raiders have had an ugly start to the season. In Week 1, they needed OT to get by Abilene Christian (52-51), a team that sits 55th in the FCS power rankings. Week 2 brought a decisive 37-16 loss at Washington State. They finally put in a good performance in Week 3, routing North Texas 66-21 as 11-point home favorites.

YouTube video

In Week 4, they get a stiff test from Arizona State, which is 3-0 both SU and ATS. The Sun Devils just went on the road and beat a solid Texas State team (31-28) that has designs on winning the Sun Belt. Red shirt freshman Sam Leavitt, a Michigan State transfer, is providing stability at the QB position that ASU hasn’t had since the Jayden Daniels days.

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As we head into Week 4 of the college football season, there are some exciting matchups on the horizon that are sure to keep fans on the edge of their seats. With several teams looking to make a statement early in the season, the odds and spreads for these games are already generating buzz among bettors and analysts alike.

One of the most anticipated games of the week is the matchup between two powerhouse programs, with Alabama taking on Georgia. Both teams are coming off impressive wins in their previous games, and this showdown is expected to be a close one. The early spread has Alabama as a slight favorite, but with Georgia’s strong defense and explosive offense, this game could go either way.

Another game to keep an eye on is the matchup between Clemson and North Carolina. Clemson has been dominant so far this season, but North Carolina has shown that they are a team to be reckoned with. The spread for this game is relatively close, with Clemson favored by a touchdown. However, North Carolina’s high-powered offense could make this game a lot closer than many expect.

In addition to these marquee matchups, there are several other games on the schedule that are sure to be entertaining. Teams like Ohio State, Oklahoma, and LSU will all be looking to continue their winning ways as they take on tough opponents in Week 4.

As for early predictions, it’s always tough to predict the outcome of college football games with certainty. However, based on the early odds and spreads, it looks like we could be in for some close and exciting games this week. Fans can expect plenty of drama and excitement as some of the top teams in the country battle it out on the gridiron.

Overall, Week 4 of the college football season is shaping up to be a thrilling one, with plenty of exciting matchups and potential upsets on the horizon. Whether you’re a die-hard fan or just a casual observer, there’s sure to be something for everyone to enjoy as we head into another action-packed weekend of college football.