Week 1 (2024) NFL Against the Spread Picks

Week 1 (2024) NFL Against the Spread Picks
Kyler Murray and Trey McBride celebrate a touchdown

Dec 17, 2023; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) and tight end Trey McBride (85) celebrates after running back James Conner (not pictured) scored a touchdown during the first quarter against the San Francisco 49ers at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports

  • Week 1 of the NFL season is finally upon us!
  • I am looking at three underdogs to cover the spread in Week 1
  • See our best Week 1 NFL picks against the spread

The NFL is back in full swing on Sunday, as 13 games kick off on September 8. There are many betting trends and angles to look at when betting on NFL Week 1, and I am utilizing those in my three best against the spread picks for Sunday.

Underdogs tend to do well in Week 1, especially when they are divisional underdogs. Divisional underdogs are 37-15-1 against the spread (71%) in Week 1 since 2014. That number gets even better for home divisional underdogs, who are 18-9-2 straight up and 23-6 ATS (79.3%) since 2009. In my Week 1 NFL best bets, I am targeting three underdogs.

Sometimes the bets in the NFL are the ugly ones that are difficult to get to the window on, but they are the right plays. Let’s dive into my favorite ATS picks for NFL Week 1.

Panthers vs Saints Odds

Team Spread Moneyline Total
Carolina Panthers +4 (−110) +160 Over 42 (−110)
New Orleans Saints -4 (−110) -190 Under 42 (−110)

Check out all the top sportsbook promo codes before locking in your NFL Week 1 bets.

ATS Picks #1: Panthers +4 (vs. Saints)

There are potentially no games that are uglier than the Panthers and Saints in Week 1, but anything over a field goal is too many points for the Saints. These two teams know each other well, and the NFL odds suggest this should be a low-scoring affair with the O/U set at 42. That in itself already points to the team getting the points. Then you look at these teams even further.

The Saints offense is nothing to ride home about, especially with Derek Carr under center. Even Alvin Kamara began showing signs of declining towards the end of last season. In the offseason, New Orleans did not do much to add to their offense, so it appears it will be a unit that struggles to score points. They hired Klint Kubiak as offensive coordinator to work on the run game that will then set up the play-action passing attack.

Despite all their struggles last season, the Panthers’ defense was solid, especially against the pass. They allowed the sixth-fewest passing yards per attempt last season and bolstered their run defense by bringing in Jadeveon Clowney and K’Lavon Chaisson. Carolina has the defense to make it difficult for New Orleans’ horrid offensive line to get any push throughout the game.

It will be difficult for the Panthers offense to be any worse than last season. Head coach Dave Canales did great things in Tampa Bay with Baker Mayfield, and now he gets to work with another No. 1 overall pick in Bryce Young. Carolina brought in wide receivers Diontae Johnson and Xavier Legette to give Young more weapons. It may take some time for the offense to gel, but they already have a better receiving corps this year than last year.

It is tough to bet on Carolina, but they went 1-1 against the spread against the Saints last season, and divisional underdogs cover the spread consistently in Week 1. Four is just too many points to lay with New Orleans, so give me the Panthers to cover.

  • Pick: Carolina Panthers +4 (-110)

Cardinals vs Bills Odds

Team Spread Moneyline Total
Arizona Cardinals +6.5 (-110) +230 Over 47.5 (−105)
Buffalo Bills -6.5 (−110) -285 Under 47.5 (−115)

ATS Picks #2: Cardinals +6.5 (vs Bills)

Another pick. Another underdog. This matchup features two teams that are trending in different directions in my opinion. The Bills lost key players in Stefon Diggs and Gabe Davis in the offseason, and their secondary is depleted. Despite their record, the Cardinals were a fun team last year late in the year. With Kyler back, their offense put up points and Arizona covered the spread in five of their last eight games. Now they have Marvin Harrison Jr. to catch the ball from Kyler Murray.

Even though Arizona almost never had the better team on paper last season, they played hard under head coach Jonathan Gannon and were in a lot of games they should not have been. I believe they will be much improved heading into Year 2, especially with Kyler able to start the year. The offense has the tools to score a lot of points against Buffalo’s backend and should be able to keep this game within a touchdown.

The betting trends also point to Arizona. In Week 1, NFL underdogs of 6.5 points or more are  27-13-1 against the spread (67.5%). To dive even deeper, NFL Week 1 road teams that won between 4-6 games the year before are 52-21-5 ATS (71.2%) since 2004. Give me the Cardinals to keep this game close.

  • Pick: Arizona Cardinals +6.5 (-110)

Titans vs Bears Odds

Team Spread Moneyline Total
Tennessee Titans +3.5 (−110) +150 Over 44.5 (−110)
Chicago Bears -3.5 (−110) −180 Under 44.5 (−110)

ATS Picks #3: Titans +3.5 (vs Bears)

The Bears have been one of the most talked about teams this offseason. Whether it comes from the incoming trio of Caleb Williams, Rome Odunze, and Keenan Allen or Hard Knocks, Chicago has a lot of hype heading into the 2024 season. While they may have a strong season, Week 1 is a different story. Quarterbacks who are drafted No. 1 overall are just 1-14-1 in their first career start since 2002. Caleb Williams is a unique talent, but that is a telling number.

While Chicago brought in a lot of weapons on the offensive side of the ball, Tennessee brought in a lot of playmakers in their secondary, most notably L’Jarius Sneed. Sneed is a true, lockdown corner and will likely cover DJ Moore. The Titans also brought in Chidobe Awuzie and some veteran safeties, making the Bears receivers vs the Titans secondary an intriguing matchup. Dennard Wilson comes over from Baltimore and plans on blitzing a lot, which could make things difficult for Caleb Williams in his first game.

The Titans offense should also be better this year with Will Levis heading into Year 2 with Calvin Ridley, DeAndre Hopkins, and Tony Pollard as weapons. Chicago’s defense should be a top unit, but this is another interesting matchup. Even if Caleb Williams can become just the second quarterback who was drafted No. 1 overall to win his first start, I doubt it will be by over a field goal. The line has already moved from Titans +4.5 to +3.5. I would have loved to get Tennessee at +4.5, but I still like them at +3.5. Give me the Titans to round out my best NFL Week 1 ATS picks.

  • Pick: Tennessee Titans +3.5 (-110)

2024 NFL ATS Picks Record: 1-0

Follow @zachreger18 on X for all his picks

  • FANATICS SPORTSBOOK

    $5M JERSEY DROP + $1,000 IN BONUS BETS

  • DRAFTKINGS SPORTSBOOK

    BET $5 & GET $250 + 1 MONTH OF NFL+ PREMIUM

  • FANDUEL SPORTSBOOK

    BET $5 & GET $200 + 3 WEEKS OF NFL SUNDAY TICKET

  • BETMGM SPORTSBOOK

    GET UP TO $1,500 BACK IN BONUS BETS + 2ND CHANCE TD CASH BACK!

  • BET365 SPORTSBOOK

    BET $5 & GET $200 IN BONUS BETS!

  • ESPN BET SPORTSBOOK

    USE CODE “DIME” & GET A $1,000 BET RESET!

  • CAESARS SPORTSBOOK

    GET UP TO $1,000 BACK – ON CAESARS!

  • Must be 21+. GAMBLING PROBLEM? Call 1-800-GAMBLER (CO, IL, KS, KY, MD, MI, NC, NJ, OH, PA, TN, VA, VT, WV, WY); (800) 327-5050 or gamblinghelplinema.org (MA); (877) 8-HOPENY (NY); 1-800-NEXT-STEP (AZ); (888) 789-7777 (CT); 1-800-BETS-OFF (IA); 1-800-9-WITH-IT (IN); mdgamblinghelp.org (MD); morethanagame.nc.gov (NC); 1800gambler.net (WV)

Author Image

NFL
NBA
MLB
NHL
Golf
Soccer
NCAAF
NCAAB
Social Media Manager; Sports Betting Personality & Handicapper

NFL
NBA
MLB
NHL
Golf
Soccer
NCAAF
NCAAB

As the 2024 NFL season kicks off, football fans and bettors alike are eagerly anticipating the start of another exciting year of action on the gridiron. One popular way for fans to get in on the action is by making against the spread (ATS) picks, where they predict whether a team will win or lose by a certain number of points.

In Week 1 of the NFL season, there are several intriguing matchups that offer bettors plenty of opportunities to make some profitable picks. Let’s take a look at some of the top games on the schedule and offer our expert ATS picks for each one.

One of the marquee matchups in Week 1 features the defending Super Bowl champions taking on a division rival. The Tampa Bay Buccaneers, led by quarterback Tom Brady, will face off against the New Orleans Saints. The Buccaneers are favored by 3 points in this game, and we like them to cover the spread and come away with a victory on the road.

Another game to keep an eye on in Week 1 is a showdown between two perennial playoff contenders, the Kansas City Chiefs and the Baltimore Ravens. The Chiefs are favored by 4 points in this game, and we believe they will cover the spread and emerge victorious in a high-scoring affair.

In a battle between two teams looking to make a statement early in the season, the Los Angeles Rams will take on the San Francisco 49ers. The Rams are favored by 2.5 points in this game, and we like them to cover the spread and pick up a key divisional win.

Finally, in a matchup between two teams with high-powered offenses, the Dallas Cowboys will face off against the Green Bay Packers. The Cowboys are favored by 1 point in this game, and we expect them to cover the spread and come away with a hard-fought victory at home.

Overall, Week 1 of the NFL season offers plenty of exciting matchups for bettors to sink their teeth into. By making informed ATS picks, fans can add an extra layer of excitement to an already thrilling season of football. Good luck with your picks!