Top Player Prop Bets for San Francisco 49ers vs Buffalo Bills on Sunday Night Football in Week 13

• The 49ers clash with the Bills in NFL Week 13 action on Sunday, December 1st, from Highmark Stadium
• Buffalo has a commanding lead in the AFC East, while San Francisco is battling to win the NFC West
• Take a look below for our top 49ers vs Bills player prop bets

Through twelve weeks of the NFL campaign, Sean McDermott’s Bills are 9-2, having won six in a row. It hasn’t been quite so easy for Kyle Shanahan and the 49ers, who are 5-6, and in an ultra-tight four-team battle to win the NFC West. As the 49ers meet the Bills on Sunday, December 1st, at Highmark Stadium in Orchard Park, NY, it’s the home squad that’s a 6-point favorite in the Week 13 NFL odds. Kickoff is scheduled for 8:20 pm ET.

49ers vs Bills Player Props

Brock Purdy’s passing yardage line is set at 224.5, while Josh Allen’s is 221.5. Khalil Shakir has the highest receiving-yardage total in the NFL player props for SNF at 54.5 for Buffalo and Jauan Jennings 51.5 for SF. As for the running backs, the Bills’ James Cook is set at 64.5 yards and the 49ers’ Christian McCaffrey is at 60.5.

 All odds as of Dec 1. Lock in this DraftKings promo code before betting on San Francisco 49ers vs Buffalo Bills Sunday night.

49ers vs Bills Prop #1: Josh Allen Passing Yards

After a slow start to the season, where Josh Allen threw for over 215 yards just twice in his first six games, he’s really started to hum of late. The Bills pivot has thrown for at least 235 yards in his last five outings, with an average of 276.6 passing yards per contest. That’s well over the listed 221.5 total.

Since 2020, Josh Allen has been the best QB in December

-1st in total TDs
-1st passing TDs
-1st in wins pic.twitter.com/Xq77Nrqa5M

— Jarrett Bailey (@JBaileyNFL) November 30, 2024

He is up against a rather stout 49ers defense, but they’re giving up 20 yards more per game through the air on the road compared to at home. With Allen expected to have wideouts Amari Cooper and Keon Coleman available, he’ll have talented players to throw to in his quest for a ton of passing yards.

• 49ers vs Bills Prop Pick: Josh Allen over 221.5 passing yards (-115); risk 1 unit at DraftKings

49ers vs Bills Prop #2: George Kittle Receptions

George Kittle continues to be a strong force and safety blanket for the 49ers. His line for this game is set at 3.5 receptions, and he’s made at least four catches in eight of his nine contests this season. He’s been a favorite go-to weapon, recording a TD in seven of nine affairs.

George Kittle among TEs in the red zone this season:

⛏️ 93.1 PFF grade (1st)
⛏️ 15 receptions (1st)
⛏️ 100 receiving yards (1st)
⛏️ 8 receiving TDs (1st)
⛏️ 10 first downs (1st)
⛏️ 5 contested catches (1st) pic.twitter.com/PT2DH7n8Ds

— PFF SF 49ers (@PFF_49ers) November 28, 2024

He’s going up against a Bills squad that is top-five in most targets allowed to tight ends, and top-ten in yards per game against TE’s. That bodes well for Kittle to be targeted early and often to make the over. John Hyslop’s 49ers vs Bills same-game parlay is also an intriguing wager you could place on this contest.

• 49ers vs Bills Prop Pick: George Kittle over 3.5 receptions (-165); risk 1 unit at DraftKings

49ers vs Bills Touchdown Scorer Props

The Bills’ James Cook has the shortest odds to find the end zone first at +500, while the 49ers’ Christian McCaffrey garners the shortest odds to record a touchdown at anytime at -125.

49ers vs Bills Prop #3: George Kittle Anytime Touchdown

If we’re going with George Kittle to blow over his 3.5 receptions total, why not pair that up with him finding pay dirt? After all, he’s recorded a TD in seven of nine games on the campaign, with a total of eight touchdowns. That leads all Niners receivers by four and is five more than any Bills wideout.

The NFL’s top 5 leaders in receiving touchdowns:

1: Ja‘marr Chase 12
2: Amon ra St-Brown 9
3: George Kittle 8
4: Terry Mclaurin 7
5: NICK WESTBROOK-IKHINE 6

— Josip ⚔️🇭🇷 (@josip_salov) November 26, 2024

The best part, he has longer odds than the top five players on the board at +220, giving you tremendous value.

If you’re also looking for a standard bet, make sure to check out Brady Trettenero’s 49ers vs Bills predictions.

• 49ers vs Bills Prop Pick: George Kittle anytime touchdown (+220); risk 1 unit at DraftKings Sportsbook

As the San Francisco 49ers prepare to take on the Buffalo Bills in a highly anticipated Sunday Night Football matchup in Week 13, fans and bettors alike are gearing up for what promises to be an exciting game. While traditional bets on the outcome of the game are always popular, player prop bets offer a unique and potentially lucrative opportunity to wager on individual player performances.

For this game, there are several intriguing player prop bets to consider. One of the top bets to watch is the over/under on 49ers quarterback Jimmy Garoppolo’s passing yards. Garoppolo has been playing well in recent weeks and could have a big game against a tough Bills defense. Bettors will need to consider factors such as the weather conditions and the Bills’ defensive strategy when making their wager.

Another player prop bet to keep an eye on is the over/under on Bills quarterback Josh Allen’s total passing touchdowns. Allen has been one of the top quarterbacks in the league this season and could have a big game against a 49ers defense that has struggled at times. Bettors will need to consider factors such as the Bills’ offensive game plan and the health of Allen’s receiving corps when making their wager.

In addition to quarterback performance, there are several other player prop bets worth considering for this game. Bettors may want to look at the over/under on 49ers running back Raheem Mostert’s rushing yards, or the over/under on Bills wide receiver Stefon Diggs’ total receiving yards. Both players have the potential to have a big impact on the game and could be worth betting on.

Ultimately, player prop bets offer a fun and exciting way to engage with the game and potentially win some money. As always, it’s important for bettors to do their research and consider all factors before placing their wagers. With the San Francisco 49ers and Buffalo Bills set to square off in what promises to be a thrilling Sunday Night Football matchup, there are plenty of player prop bets to keep fans and bettors entertained throughout the game.