Predictions, Picks, and Best Odds for San Francisco 49ers vs Seattle Seahawks on Thursday Night Football in Week 6

• The 2-3 San Francisco 49ers visit the 3-2 Seattle Seahawks in an important NFC West clash on TNF
• The Seahawks have lost to straight after a 3-0 start while the Niners have dropped two of three to fall under .500
• See the 49ers vs Seahawks picks, predictions, and best available odds for Thursday Night Football

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Two NFC West teams mired in slumps will meet on Thursday Night Football in Week 6 as the Seattle Seahawks (3-2, 2-1 home, 1-3-1 ATS) host the San Francisco 49ers (2-3, 0-2 away, 2-3 ATS) at Lumen Field at 5:15 pm PT/8:15 pm ET. Still without Christian McCaffrey and battling a rash of other injuries, the 49ers head into Seattle as 3.5-point road favorites in the current football betting lines.

San Francisco 49ers vs Seattle Seahawks Predictions & Picks

Sascha Paruk’s 2024 NFL picks: 13-15 (-1.17 units)

Coming off by far their most disappointing performance of the season – a 29-20 loss at home to the Giants as 7.5-point favorites – the Seahawks now find themselves catching more than a field goal against the banged-up 49ers, who suffered their own devastating setback in Week 5 when they fell 24-23 to the Cardinals also as 7.5-point home chalk. San Francisco was shutout in the entire second half, blowing a 23-10 lead at the break.

In addition to McCaffrey, the Niners have a litany of injuries on the defensive side of the ball. Five starters are either out or questionable on a short week: Charvarius Ward (questionable, knee), Demetrius Flannigan-Fowles (questionable, calf), Ji’Ayir Brown (questionable, ankle), Jordan Elliott (questionable, knee), and safety Talanoa Hufanga (out, wrist).

Tight end George Kittle is also questionable with a rib injury.

George Kittle, Fred Warner remain limited on Tuesday’s estimated injury report. https://t.co/vO1yBGsNEx

— ProFootballTalk (@ProFootballTalk) October 9, 2024

The Seahawks injury situation isn’t nearly as dire. No one of any significance on the offense has an injury designation (though OT George Fant remains on IR). On defense, linebacker Derick Hall (foot), cornerback Riq Woolen (ankle), and free safety Julian Love (hamstring) are all questionable.

The 49ers have won four straight against the Seahawks, including two in a row in Seattle, and all four games were fairly lopsided. The smallest margin of victory was eight points and the average was 14.5. But I’ve seen enough over the last four weeks to downgrade the Niners pretty significantly. Their shorthanded defense isn’t dominating the way it used to, and the offense isn’t the same without McCaffrey.

Heading into Week 6, the Seahawks actually rank higher than the Niners in DVOA (8th vs 9th). Purdy and his talented group of pass catchers will still put up some points, which is why I’m also taking the over, but I love the Seahawks catching a field goal plus the hook at home.

Best Available 49ers vs Seahawks Odds

There is a very little variation in the spread across different sportsbooks. Every book currently has the line at 49ers -3.5 (up half a point from the opening odds, which were 49ers -3). The only difference is a slight discrepancy the odds. BetMGM currently lists San Fran -3.5 at -105 odds, which is the longest bettors will find. Caesars Sportsbook has the longest price on Seattle +3.5, which is also -105.

There are bigger differences with respect to the moneyline and the total. The best moneyline price for a Seattle SU victory is +158 at Caesars. (It’s as short as +142 at FanDuel.) The longest odds on the Niners to win straight-up are -176 at FanDuel.

There is also a full point difference in the game total with ESPN Bet listing it at 49.5 (O -115/U -105) and FanDuel listing it at 48.5 (O -105/U -115).

The San Francisco 49ers will face off against the Seattle Seahawks in a highly anticipated Thursday Night Football matchup in Week 6 of the NFL season. Both teams are coming off strong performances in Week 5 and will be looking to continue their winning ways.

The 49ers are currently sitting at 2-3 and are coming off a dominant 31-7 victory over the Arizona Cardinals. Quarterback Jimmy Garoppolo had a solid performance, throwing for 268 yards and two touchdowns. The 49ers defense also stepped up, holding the Cardinals to just 7 points and forcing three turnovers. The team will look to build on this momentum and secure a win against their division rival.

On the other side, the Seahawks are currently 2-2 and are coming off a thrilling 28-21 victory over the Los Angeles Rams. Quarterback Russell Wilson had a stellar performance, throwing for 221 yards and two touchdowns. The Seahawks defense also played well, holding the Rams to just 21 points. The team will look to continue their winning ways and improve their record with a win over the 49ers.

In terms of predictions, this game is shaping up to be a close one. Both teams have shown flashes of brilliance on both sides of the ball and have the potential to come out on top. However, the Seahawks may have a slight edge due to their experience and the leadership of Russell Wilson.

As for picks, it may be wise to consider betting on the Seahawks to win this matchup. They have a strong offense led by Wilson and a defense that has shown improvement in recent weeks. The 49ers will put up a fight, but the Seahawks may have the upper hand in this game.

In terms of best odds, sportsbooks are currently favoring the Seahawks to win this game. The odds may fluctuate leading up to kickoff, so it’s important to keep an eye on them and make your bet accordingly.

Overall, this Thursday Night Football matchup between the San Francisco 49ers and Seattle Seahawks is shaping up to be an exciting one. Both teams have the potential to come out on top, but the Seahawks may have a slight edge in this divisional showdown. It will be interesting to see how it all plays out on game day.