Predictions for Week 4 College Football Games with Point Spreads

• Check out our Week 4 college football picks against the spread for Saturday (Sep. 21)
• We’re off to a red-hot start in our 2024 CFB ATS picks; can we keep it up?
• Below, see my best Week 4 college football picks against the spread, including a play on USC

We’re off to a promising start with our 2024 college football picks against the spread, and we’re aiming to keep the momentum going. Week 4 presents another full slate of games to capitalize on with our ATS wagers.

In my Week 4 college football picks against the spread, I’m targeting a couple of intriguing favorites and one massive underdog. Among my top Week 4 CFB picks against the spread is a play on USC in their marquee matchup with Michigan.

Let’s dive into our expert college football picks against the spread for Week 4 (Saturday, September 21st).

CFB ATS Picks Week 4

USC vs Michigan Odds

All odds as of September 18th at ESPN Sportsbook. Check out the best football betting apps for college football against the spread betting.

ATS Pick #1: USC -5 (vs Michigan)

Kicking off my Week 4 college football picks against the spread is a play on the USC Trojans in their marquee matchup with the Michigan Wolverines. This line has completely shifted since Michigan opened as notable favorites during the offseason.

However, while USC is no longer plus-money, I like them to win by at least one score. USC has been impressive to start the season, upsetting LSU in Week 1 and shutting out Utah State 48-0 in Week 2 before enjoying a bye last week.

Quarterback Miller Moss has excelled in replacing Heisman winner Caleb Williams, throwing for 600 yards and two TDs in USC’s first two victories. The Trojans defense has also been a pleasant surprise, allowing just 100 rushing yards per game and ranking 55th nationally in total defense.

The Heisman Race is arguably wide open right now, does Miller Moss take the lead with a big performance vs Michigan this week? ✌️

(@SSN_USC / @FightOnRusty)
pic.twitter.com/UUbCZoI2WA

— SleeperCFB (@SleeperCFB) September 17, 2024

USC should be able to stack the box and dare Michigan to throw, a risky proposition for the Wolverines who are turning to the unproven Alex Orji at quarterback this week.

The Wolverines have truly struggled out of the gate in their national title defense. Michigan lost 31-12 at home to Texas and barely held off Arkansas State 28-18 last week as 21-point favorites.

Michigan’s passing game has been anemic, with just 134 yards and three interceptions against Arkansas State. Unless Orji provides a major spark, it’s hard to see the Michigan offense keeping pace with USC for four quarters, even with the game in Ann Arbor.

• Pick: USC -5 (-110)

Arkansas vs Auburn Odds

ATS Pick #2: Arkansas +3 (vs Auburn)

Another addition to my Week 4 college football picks against the spread is a play on the Arkansas Razorbacks in their SEC tilt with the Auburn Tigers. Both teams are sitting at 2-1, but I see all the value on the road underdog here.

This line has moved from Auburn -4 to -3 despite the Tigers getting the majority of bets in the college football public betting splits. This tells us where the sharp money is on this game. Short road underdogs of 4 points or less have covered in 72% of games so far this season.

The last time Arkansas lost on the road at Auburn pic.twitter.com/9CMsmiJ5Tj

— JC Hoops (@JacksonCollier) September 18, 2024

Arkansas impressed by upsetting Oklahoma State on the road as 10-point underdogs just two weeks ago before beating UAB in Week 3. Dual-threat quarterback Taylen Green has given opponents fits with his rushing ability, amassing 245 yards on the ground through three games.

Auburn made a quarterback change last week, benching veteran Payton Thorne in favor of freshman Hank Brown. While Brown impressed with four touchdowns against New Mexico, the Lobos have a miserable defense.

Given some uncertainty at QB for Auburn, I expect the Tigers to rely heavily on star running back Jarquez Hunter. However, he’ll be facing a stout Arkansas defensive front led by preseason All-SEC pick Landon Jackson.

• Pick: Arkansas +3 (-110)

UCLA vs LSU Odds

ATS Pick #3: UCLA +24.5 (vs LSU)

Concluding my Week 4 college football picks against the spread is a play on the UCLA Bruins as massive 24.5-point underdogs against the LSU Tigers. Yes, the Bruins are not a strong team this season, but I don’t think they will get completely blown out by the Tigers.

UCLA’s defense has also shown some promising signs early in the season. They are currently allowing just 87 rushing yards per game, which ranks 29th in the nation. The Tigers rank second-last in the SEC in rushing offense after losing at running back following a season-ending injury to John Emery.

LSU RB John Emery announces on his Instagram that he’s having surgery on his torn ACL Thursday. pic.twitter.com/aOaZpNJVd7

— LouisianaSportsDotNet (@LASportsDotNet) September 5, 2024

Another factor to consider is that LSU has struggled to cover big numbers in recent years. In fact, the Tigers are just 1-4 against the spread in their last five games as a favorite. They have also covered just three times in their last 12 games during the season’s opening month.

UCLA QB Ethan Garbers isn’t setting the world on fire with his 54.1% completion percentage this season, but he’s at least experienced playing in hostile environments. I expert his familiarity with the offense and dual-threat ability to help keep UCLA within three scores.

• Pick: UCLA +24.5 (-110)

Brady’s 2024 CFB ATS Picks Record: 10-2

As we head into Week 4 of the college football season, there are several exciting matchups on the schedule that are sure to have fans on the edge of their seats. With point spreads being a popular way to gauge the potential outcome of a game, let’s take a look at some predictions for this week’s games.

One of the most highly anticipated matchups of the week is between two top-10 teams, with Alabama taking on Florida. The Crimson Tide are currently favored by 14 points in this game, and it’s easy to see why. Alabama has looked dominant so far this season, while Florida has had some struggles on both sides of the ball. Look for Alabama to cover the spread and come out on top in this one.

Another game to keep an eye on is the matchup between Penn State and Auburn. The Nittany Lions are favored by 6 points in this game, and it should be a close one. Both teams have looked strong early in the season, but Penn State’s defense has been particularly impressive. Look for them to cover the spread and come away with a win at home.

In a battle of two undefeated teams, Michigan State will take on Miami. The Spartans are favored by 6.5 points in this game, and they have looked solid on both sides of the ball so far this season. Miami, on the other hand, has had some struggles on offense. Look for Michigan State to cover the spread and remain undefeated.

Lastly, keep an eye on the matchup between Notre Dame and Wisconsin. The Fighting Irish are favored by 6.5 points in this game, but Wisconsin has looked strong early in the season. This game could go either way, but I expect Notre Dame to cover the spread and come away with a hard-fought victory.

Overall, Week 4 of college football is shaping up to be an exciting one, with several intriguing matchups and potential upsets on the horizon. Keep an eye on these games and be sure to tune in to see how it all plays out.