Houston vs Duke Final Four Odds: Spread, Moneyline & Total Available for Betting

• The East #1 Duke Blue Devils will meet the Midwest #1 Houston Cougars in the Final Four next Saturday, April 5
• Duke, the top-rated and top-ranked team in the country, has opened as the betting favorite
• See the opening Houston vs Duke odds, including point spread, game total, and moneyline

The #1 Duke Blue Devils (35-3, 25-13 ATS, 20-18 O/U) cruised through the East Region with a 23.5-point average margin of victory, booking their ticket to San Antonio with an 85-65 rout of #2 Alabama on Saturday. On Sunday afternoon, the Midwest #1 Houston Cougars (34-4, 19-17-1 ATS, 15-21-1 OU) earned the right to meet Duke in the 2025 Final Four next Saturday, April 5, at the Alamodome. At the time of publication, Houston owned a 62-45 lead on #2 Tennessee with three minutes remaining. The opening Houston vs Duke odds favor the top-ranked Blue Devils reaching the championship game for the first time in a decade.

Houston vs Duke Odds

The Houston vs Duke spread has opened with the Blue Devils as sizable 5.5-point favorites and -215 chalk on the moneyline, amounting to a 68.25% implied win probability. The Cougars come back as +176 underdogs (36.23% implied win probability). The game total is 135.5 with -110 odds both ways

Odds as of March 30 at FanDuel. Get the latest March Madness betting promos before the 2025 NCAA Tournament comes to a close.

Duke’s Road to the Final Four

The Blue Devils looked the part of the top team in the country throughout their first four games. After nearly doubling up on #16 Mount Saint Mary’s (94-49), Duke cruised past #9 Baylor (89-66) before bouncing #4 Arizona (100-93) in the Sweet 16 in a game that was not as close as the final score suggests. The Blue Devils led by double-digits from the 23-minute mark to the 36-minute mark and their win probability was over 90% for the entire second half.

Arguably their best performance of the tournament came last night against #2 Alabama. Duke held the prolific Crimson Tide, who had scored 80-plus in seven straight games and were averaging to just 65 points 94.3 PPG in the tournament, to just 65 points, their second-lowest output of the season.

Four of five starters scored at least 14 points, led by 21 from Kon Knueppel (14.4 PPG, 3.9 RPG, 2.8 APG). Cooper Flagg (18.9 PPG, 7.5 RPG, 4.2 APG), the favorite in the Wooden Award odds, added 16 points, nine rebounds, three assists, and a block.

Houston vs Duke Ratings Comparison

Ratings for Houston are from prior to their Elite Eight victory.

The storylines heading into San Antonio will be Duke’s top-rated offense against Houston’s top-rated defense. But don’t sleep on the opposite side for either team. KenPom rates Houston’s defense 12th in the nation, but it’s as high as fourth at Haslam. The Cougars have scored 72-plus points in six of their last seven games.

Duke, of course, had one of the best defensive performances of the tournament against Alabama. The Blue Devils currently sit fourth in D-Rating at both KenPom and Haslam.

Houston’s Path to the Final Four

The Cougars demolished #16 SIUE (78-40) before taking down #8 Gonzaga (81-76) in a game they controlled from the opening tip. Purdue, the #4 seed in the Midwest, was a trickier mistress in the Sweet 16. Houston had a comfortable 10-point lead with eight minutes remaining but a late Purdue flurry managed to tie the game at 60 with 35 seconds to play.

A genius inbound play from Kelvin Sampson’s group gave Houston a 62-60 win almost as time expired.

In the Elite Eight against #2 Tennessee, the Cougars looked the part of a #1 seed and the Big 12 regular-season and tournament champions; Houston raced out to a 31-12 lead and maintained that 19-point margin into halftime (34-15). Tennessee made a bit of a push in the final 20 minutes, trimming the lead to single-digits with just under five to play. But Houston’s lead was never seriously threatened.

Leading scorer LJ Cryer (15.3 PPG, 2.1 RPG, 2.0 APG) had a team-high 17 points with seven rebounds and four assists. Emmanuel Sharp (12.6 PPG, 3.0 RPG) added 16,

The Final Four of the NCAA Men’s Basketball Tournament is fast approaching, and one of the highly anticipated matchups is between the Houston Cougars and the Duke Blue Devils. Both teams have had impressive seasons so far, and fans are eagerly awaiting to see who will come out on top in this showdown.

For those looking to add some excitement to the game, betting on the outcome is a popular option. Sportsbooks have released the odds for the Houston vs Duke matchup, including the spread, moneyline, and total points available for betting.

As of now, Duke is favored to win the game with a spread of -4.5 points. This means that in order to win a bet on Duke, they must win by at least 5 points. On the other hand, Houston is the underdog with a spread of +4.5 points, meaning they can either win the game outright or lose by 4 points or less for a bet on them to be successful.

In terms of the moneyline, Duke is listed at -200, while Houston is listed at +175. This indicates that Duke is the favorite to win the game straight up, but a bet on Houston would result in a higher payout if they were to pull off the upset.

The total points for the game is set at 140.5, with bettors able to wager on whether the total combined score of both teams will be over or under that number.

It’s important for bettors to do their research and consider factors such as team statistics, injuries, and recent performance when placing their bets. Both Houston and Duke have talented rosters and strong coaching staffs, making this Final Four matchup a tough one to predict.

As always, it’s crucial to gamble responsibly and only bet what you can afford to lose. The Final Four is sure to be an exciting event, and adding a little extra thrill with a wager can make it even more enjoyable for fans. Good luck to all those placing bets on the Houston vs Duke game!