Guide to NFL Draft Betting: Top Picks for Second, Third Overall Selections & Position Props

• There is no shortage of NFL Draft odds to wager on
• Bettors can place bets on where players will be selected, in addition to position props
• Read below for 2025 NFL Draft odds and predictions, plus best bets

Cam Ward is all but a lock to go to the Tennessee Titans at first overall in the 2025 NFL Draft, according to oddsmakers. While there’s not much value in betting Ward to go first overall anymore, there are still plenty of NFL Draft props we can dive into to make some money.

DraftKings is going all in with their 2025 NFL Draft props, providing us bettors with odds for everything from the second and third selections, to the first WR and first RB taken in the Draft.

Here is a look at the odds for some of these unique NFL Draft betting markets, as well as my prediction and best bets.

Jump to: Second Overall Pick | Third Overall Pick | First RB Selected | First WR Selected

NFL Second Overall Pick Odds

Abdul Carter leads the Number 2 Pick market at -130 odds (56.5% implied probability), followed by Shedeur Sanders at +185 (35.1%).

Odds as of March 26, 2025, at DraftKings Sportsbook. Claim the DraftKings promo code to bet on the 2025 NFL Draft. Odds subject to change.

Shedeur Sanders Worth a Bet at 2nd Overall?

Abdul Carter might be the betting favorite (-130) to go second overall, but I’m eyeing Colorado QB Shedeur Sanders at +185 as my value play. The Browns desperately need a QB after the Deshaun Watson disaster, and Sanders fits Kevin Stefanski’s offense like a glove.

Sanders put up monster numbers in his final college season, throwing for 4,134 yards with 37 TDs and just 8 INTs while leading Colorado to a 9-4 record. His accuracy and anticipation throwing are exactly what the Browns are looking for in their next signal-caller.

The Myles Garrett situation initially pushed Carter’s odds through the roof, but with Garrett now getting paid and likely staying put, the Browns can focus on finding their franchise QB. NFL analyst Bucky Brooks ranks Sanders as his top QB in the class, praising his “plus arm talent and superb touch, timing and anticipation – all traits that translate perfectly to Stefanski’s scheme.

At +185 (35% implied probability), Sanders to Cleveland represents tremendous value for a player who’s widely projected to go in the top 5. While Carter’s the flashier name right now, QB remains king in the NFL Draft. I’m hammering Sanders at this price point before the odds inevitably shorten.

NFL Third Overall Pick Odds

Travis Hunter is favored for the third selection at -150 (60.0% implied probability), with Shedeur Sanders second at +170 (37.0%). -150 may seem like heavy juice to pay, but it’s actually great value if you feel the chances of him going third are closer to the 80-90% range (like myself).

Giants Should Lock In Hunter With 3rd Pick

With Shedeur Sanders likely heading to Cleveland at No. 2, the Giants have a no-brainer at the third pick: Colorado two-way star Travis Hunter. At -150 odds, Hunter is solid value as the draft’s most gifted athlete.

After signing Russell Wilson and Jameis Winston this offseason, the Giants no longer face QB desperation at No. 3. This frees them to take the best player available – and that’s clearly Hunter, the Heisman winner who dominated as both an elite cornerback and receiver at Colorado.

Hunter fits the Giants perfectly. On offense, he pairs with Malik Nabers to give New York two young playmakers. On defense, he steps in as an instant CB1. The Giants plan to use him mainly at corner, but Brian Daboll will surely find ways to unleash his receiving skills, too.

With veteran QBs now in place, the Giants can be patient. They can take Hunter at No. 3 while possibly targeting Jaxson Dart later via trade-up. This approach gives them the draft’s most unique talent while still addressing quarterback.

The Giants would be foolish to pass on a generational talent who can transform their team on both sides of the ball. Hunter to the Giants at No. 3 is one of the safest bets on the NFL Draft board.

NFL First Running Back Selected Odds

Ashton Jeanty dominates the first RB market at -2500 (96.2% implied probability), with Omarion Hampton a distant second at +1000 (9.1%).

Finding Value in the First RB Selected Odds

Ashton Jeanty is the very heavy favorite at -2500 to be the first running back taken, and for good reason. However, running backs have been one of the more unpredictable markets in the NFL Draft, making a few players worthy of a sprinkle bet to get picked before the Boise State stud.

Why Omarion Hampton at +1000 is Worth a Small Bet

Jeanty may be the overwhelming favorite to be the first running back selected in the 2025 NFL Draft. But at those odds, you’d need to risk $2,500 just to win $100 – terrible value for a draft that’s still a month away. Instead, bettors should look at North Carolina’s Omarion Hampton at +1000, where a $100 bet returns $1,000.

Hampton is widely considered the clear RB2 in this class, but the gap between him and Jeanty isn’t as wide as the odds suggest. Hampton brings NFL-ready size (6’0″, 220 pounds) with impressive burst and power. His 2024 season was stellar, rushing for 1,660 yards and 15 touchdowns while showing legitimate three-down ability.

What makes Hampton worth the bet? NFL teams are notoriously unpredictable with running backs. Just a couple years ago, Bijan Robinson was the consensus RB1 but Jahmyr Gibbs surprisingly went just two picks later. Hampton offers a more traditional NFL build than the 5’8″ Jeanty and has fewer durability concerns given his stout frame.

The Browns, Cowboys and Giants all pick in the top 50 and need running back help. If any of them prefer Hampton’s bruising style to Jeanty’s shiftiness, this long shot could cash. At +1000, you’re getting tremendous value on a player who some scouts believe is just as talented as the heavy favorite.

Don’t Sleep on TreVeyon Henderson

For those looking for an even bigger payoff, TreVeyon Henderson at +5000 deserves consideration. The Ohio State star possesses elite speed and big-play ability that NFL teams covet. His 4.43 40-yard dash at the Combine confirmed what the tape shows – Henderson can score from anywhere on the field.

Henderson’s injury history is the main reason for his long odds, but his upside is undeniable. He averaged an impressive 6.4 yards per carry over his college career and has the explosiveness that teams like Buffalo or Philadelphia might prioritize in their offensive systems.

While Jeanty will likely be the first back selected, the NFL Draft is all about finding value. Hampton at 10-1 and Henderson at 50-1 offer that in spades, making them smart sprinkle bets instead of laying -2500 on Jeanty – regardless of how talented the Boise State star may be.

NFL First Reciever Drafted 2025 Odds

Tetairoa McMillan leads the WR board at -235 (70.1% implied probability), with Matthew Golden the main challenger at +170 (37.0%).

Best Value Bet for First WR Taken

Just like the previous category, I actually believe there is solid value in fading the favorite in this NFL Draft prop and making a plus-money wager on the next guy down.

Golden’s Stock Is Soaring

While McMillan sits as the -235 favorite to be the first wide receiver selected, Matthew Golden is my best value bet at +170. The Texas speedster has been climbing draft boards since his eye-popping 4.29 40-yard dash at the NFL Combine – the fastest among all receivers.

Golden brings a modern NFL skill set that teams covet. His elite speed, route-running precision, and production at Texas (987 yards, 9 TDs in 2024) have scouts buzzing. NFL Network’s Bucky Brooks recently elevated Golden in his position rankings, noting his ability to “blow past defenders on vertical routes or utilize his crafty route-running skills to separate.”

McMillan’s stock has been trending in the opposite direction. Once considered a lock for the top-10, many analysts now project him sliding into the 12-20 range. At 6’4″, he dominates contested catches but lacks the separation ability that NFL teams increasingly prioritize.

The NFL’s Need for Speed

The modern NFL values separation over size, and Golden delivers exactly what teams want. His versatility to line up inside or outside while threatening defenses vertically makes him an ideal fit for teams picking early like the Giants (3), Cardinals (4), or Chargers (5).

NFL evaluators are increasingly prioritizing receivers who can create instant separation – and Golden excels in this area. FOX Sports analyst Joel Klatt highlighted this after Golden’s Combine performance: “He’s not just a track star, he makes plays. The passing game for Texas largely ran through Matthew Golden.”

At +170, I like the value on Golden right now. While McMillan may still be the slight favorite, Golden’s combination of elite measurables and production makes him a smart bet to be the first receiver off the board on draft night.

The NFL Draft is one of the most exciting events in the football world, as teams have the opportunity to select the best college players to add to their roster. With the draft comes a flurry of betting opportunities for fans looking to add some extra excitement to the event. In this guide, we will take a look at some top picks for the second and third overall selections, as well as some position props to consider when placing your bets.

Second Overall Selection:
The second overall pick in the NFL Draft is often a highly coveted position, as teams look to secure a top talent to add to their roster. In recent years, quarterbacks have been a popular choice for this pick, as teams look to find their franchise signal-caller. Some top prospects to consider for the second overall pick in the 2021 draft include quarterbacks Justin Fields from Ohio State and Zach Wilson from BYU. Both players have shown impressive skills and could be strong contenders for this spot.

Third Overall Selection:
The third overall pick is another important position in the draft, as teams look to add a key player to their roster. This pick is often used to select a player who can make an immediate impact on the team. Some top prospects to consider for the third overall pick in the 2021 draft include quarterback Trey Lance from North Dakota State and wide receiver Ja’Marr Chase from LSU. Both players have shown impressive skills and could be strong contenders for this spot.

Position Props:
In addition to betting on specific players to be selected with the second and third overall picks, there are also a number of position props to consider when placing your bets. Some popular position props include betting on the first quarterback, running back, or wide receiver to be selected in the draft. You can also bet on which position will have the most players selected in the first round, or which position will have the fewest players selected.

When placing your bets on position props, it’s important to consider the strengths and weaknesses of each position in the draft class. For example, if there are a number of top-tier quarterbacks available, you may want to consider betting on the first quarterback to be selected. On the other hand, if there are few standout running backs in the draft class, you may want to consider betting on a different position prop.

Overall, the NFL Draft offers a wide range of betting opportunities for fans looking to add some extra excitement to the event. By considering top picks for the second and third overall selections, as well as position props, you can make informed bets and potentially win big during this exciting event.