Early NFL Week 2 Picks Against the Spread: Bengals vs Chiefs, Saints vs Cowboys among Targeted Matchups

Early NFL Week 2 Picks Against the Spread: Bengals vs Chiefs, Saints vs Cowboys among Targeted Matchups
Dallas Cowboys running back Ezekiel Elliott after picking up a first down

Sep 8, 2024; Cleveland, Ohio, USA; Dallas Cowboys running back Ezekiel Elliott (15) celebrates his first down run against the Cleveland Browns during the fourth quarter at Huntington Bank Field. Mandatory Credit: Scott Galvin-Imagn Images

  • The NFL Week 2 odds are out and there are a few lines I’m targeting early on
  • Coming off the biggest upset of Week 1, the Patriots are home underdogs to the Seahawks
  • See my three favorite Week 2 NFL picks against the spread

While Week 1 doesn’t officially wrap up until tonight, when the Jets and 49ers clash on Monday Night Football, the Week 2 NFL odds are out and there is no time like the present to find some vulnerable lines.

The table below lists my three favorite Week 2 ATS picks in chronological order.

Week 2 NFL Picks Against the Spread

Matchup Pick Date/Time
Saints vs Cowboys Cowboys -6.5 (-115) at BetMGM Sunday, Sep. 15 (1:00 pm ET)
Seahawks vs Patriots Patriots +3.5 (-108) at DraftKings Sunday, Sep. 15 (1:00 pm ET)
Bengals vs Chiefs Chiefs -5.5 (-115) at FanDuel Sunday, Sep. 15 (4:25 pm ET)

My Week 1 ATS picks are 2-0 heading into the Jets vs 49ers matchup on Monday Night Football, where I’m on the Niners -3.5. Overall, my 2024 NFL picks are 4-2 (+1.64 units).

Odds as of Sep. 9. Download the top NFL betting apps for the 2024 season. 

Week 2 ATS Pick #1: Cowboys (-6.5) Over Saints

The Dallas Cowboys were arguably the most-impressive team in Week 1, crushing the Browns 33-17 on the road in Cleveland, a game they led 20-3 at halftime. Dak Prescott wasn’t great in his first game since becoming the highest-paid player in the league, going just 19/32 for 166 yards and a TD. But keep in mind he was facing a top-five defense.

The Dallas defense, meanwhile, was exceptional, generating three takeaways and holding Cleveland to just 237 total yards (137 passing).

The Saints demolished the league-worst Panthers, 47-10, at home in Week 1 but I expect a week of massive regression from New Orleans QB Derek Carr, who was 19/23 for 200 yards and three TDs against Carolina’s abysmal defense.  Carr has never been anything more than a league-average pivot and New Orleans has one of the weaker receiver groups in the NFL.

I expect Dallas, regular-season powerhouse that they are, to win this one going away. Early money is pouring in on the Cowboys, who are getting 93% of ATS handle so far in the Week 2 NFL public betting splits, so don’t hesitate if you want to bet Dallas. This line is going to grow.

Week 2 ATS Pick #2: Patriots (+3.5) Over Seahawks

Anyone who thinks New England’s 16-10 win over the heavily-favored Bengals in Week 1 was a fluke should go back and watch the tape. Yes, New England had the benefit of some timely turnovers, and that’s not sustainable. But the Pats were nonetheless the better team. Their offensive line did a phenomenal job of protecting Jacoby Brissett (one sack) while also opening big holes for RB Rhamondre Stevenson, who finished with 120 yards on 25 carries.

The New England defense caused all sorts of problems for Joe Burrow and company, who were held to just 154 passing yards and 224 yards total.

The Seahawks took care of business at home against the Broncos (26-20) but now have to fly across the country for a 1 pm ET start, a notoriously difficult trip for west-coast teams. Whether the Pats’ offense plays as well in Week 2 as it did in Week 1, New England’s legit defense will keep this game close. Even during a dismal 4-13 campaign last season, the Patriot defense was top-ten in DVOA, and they’ve only gotten better over the summer.

Week 2 ATS Pick #3: Chiefs (-5.5) Over Bengals

Cincinnati was not ready to play in Week 1, and flipping the switch in Week 2 at Arrowhead is going to be a tall order to say the least. Kansas City started its quest for an unprecedented three-peat with a hard-fought 27-20 home win over the Ravens, a legitimate Super Bowl contender in its own right, and I expect Patrick Mahomes and company to completely shred a porous Cincinnati defense.

Despite little to no deep passing threats, the Patriots were able to run over the Bengals front-seven. If Cincinnati puts eight in the box to contain Isiah Pacheco, the Chiefs will pick them apart through the air. The addition of rookie Xavier Worthy has given Mahomes much-needed speed on the outside, and it’s possible Marquise “Hollywood” Brown will be back for Week 2.

Even if he’s not, Rashee Rice (109 yards on seven catches in Week 1) is blossoming into a bona fide star in his own right. I won’t be the least bit surprised if KC wins this game by two touchdowns or more. Already favored in the 2025 Super Bowl odds, KC’s futures are going to get shorter in the coming weeks.

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As we head into Week 2 of the NFL season, there are several intriguing matchups on the schedule that have caught the attention of bettors and analysts alike. Two games in particular that are generating a lot of buzz are the Cincinnati Bengals vs Kansas City Chiefs and the New Orleans Saints vs Dallas Cowboys.

The Bengals are coming off a disappointing loss to the Los Angeles Chargers in Week 1, while the Chiefs put on an impressive offensive display in their win over the Cleveland Browns. Despite their struggles in Week 1, the Bengals are still a talented team with a dynamic offense led by quarterback Joe Burrow and wide receiver Ja’Marr Chase. The Chiefs, on the other hand, are one of the favorites to win the AFC this season thanks to their high-powered offense led by quarterback Patrick Mahomes.

When it comes to betting on this game, the Chiefs are currently favored by around 3.5 points. While the Bengals have the potential to keep this game close, it’s hard to bet against Mahomes and the Chiefs’ explosive offense. Look for Kansas City to cover the spread in this matchup.

In the Saints vs Cowboys game, both teams are coming off impressive wins in Week 1. The Saints dominated the Green Bay Packers, while the Cowboys pulled off a thrilling comeback victory over the Tampa Bay Buccaneers. This game is shaping up to be a battle between two high-powered offenses, with quarterbacks Jameis Winston and Dak Prescott looking to lead their teams to victory.

The Cowboys are currently favored by around 3 points in this matchup, but the Saints have shown that they are a force to be reckoned with on both sides of the ball. This game could go either way, but with the Saints playing at home in the Superdome, they have a slight edge. Look for New Orleans to cover the spread in what should be a close and exciting game.

Overall, Week 2 of the NFL season is shaping up to be an exciting one with several intriguing matchups on tap. Bettors should keep an eye on these targeted matchups and consider placing their bets accordingly.