Analysis of MLB Opening Day Odds and Picks for All 14 Games

• All but two MLB teams are in action on Opening Day 2025 (March 27)
• I have set out the odds for all 14 games, including moneyline, runline and run total
• See my MLB Opening Day picks and predictions for each game on the docket

The 2025 MLB season technically started last week with the Cubs and Dodgers meeting in a two-game set in Japan. But, for the vast majority of the league, Thursday, March 27, marks Opening Day on the new season. In the table below, I have set out the odds (moneyline, spread, and total) for all 14 games on the MLB slate on Thursday. Under the table, find my pick for each game, along with the sportsbook that currently has the best available odds for that pick.

MLB Opening Day Odds 2025

Note that the odds in the table above are from DraftKings on March 26. In the table below, which sets out my favorite picks for each game, I have culled the best odds for that pick from one of five books: DK, FanDuel, Caesars, bet365, and BetMGM.

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With every team sending their de facto ace to the mound on Opening Day, there aren’t any hugely lopsided moneyline odds among the 14 games on the slate. Zack Wheeler and the Philadelphia Phillies (-175) are the biggest favorite of the day on the road against Mackenzie Gore and the Washington Nationals. The Mariners (-170) are the only team team shorter than -164.

The run totals range from a mager 6.5 in Pirates vs Marlins to 8.5 in a trio of games: Tigers vs Dodgers, Cubs vs Diamondbacks, and Orioles vs Blue Jays.

MLB Opening Day Picks & Predictions

All wagers one unit unless expressly stated otherwise.

The vast majority of my MLB Opening Day picks are moneyline wagers, with eight of them on a plus-money underdog to win outright. Four of those are home underdogs.

I’m also targeting two first-X unders: under 1.5 in the first three innings between the Pirates and Marlins, and under 2.5 in the first five innings between the Braves and Padres. Both are electric pitching matchups. Pittsburgh sends Paul Skenes, the preseason favorite in the Cy Young odds, to the hill opposite Miami’s Sandy Alcantara, the 2022-winner.

The Braves give the opening-day start to reigning NL Cy Young-winner Chris Sale, who toes the rubber against Padres ace Michael King.

The MLB season is finally upon us, and with it comes the excitement of Opening Day. With 14 games scheduled for the first day of the season, fans and bettors alike are eager to see how their favorite teams will perform. In this article, we will take a closer look at the odds and picks for each of the 14 games on Opening Day.

1. Toronto Blue Jays vs. New York Yankees
The Yankees are favored to win this matchup, with odds of -150. However, the Blue Jays have a strong lineup and could pull off an upset. Our pick: Yankees to win.

2. Baltimore Orioles vs. Boston Red Sox
The Red Sox are heavy favorites in this game, with odds of -200. The Orioles are rebuilding and are not expected to put up much of a fight. Our pick: Red Sox to win.

3. Detroit Tigers vs. Cleveland Guardians
The Guardians are the favorites in this game, with odds of -120. The Tigers have a young and talented team, but the Guardians have the edge in this matchup. Our pick: Guardians to win.

4. Minnesota Twins vs. Seattle Mariners
The Twins are slight favorites in this game, with odds of -110. The Mariners have a solid pitching staff, but the Twins’ offense should give them the edge. Our pick: Twins to win.

5. Chicago White Sox vs. Los Angeles Angels
The White Sox are favored to win this game, with odds of -130. The Angels have a strong lineup, but the White Sox have a deeper roster. Our pick: White Sox to win.

6. Kansas City Royals vs. Texas Rangers
The Royals are favored in this game, with odds of -140. The Rangers are rebuilding and are not expected to be competitive this season. Our pick: Royals to win.

7. Houston Astros vs. Oakland Athletics
The Astros are favored in this game, with odds of -160. The Athletics have a solid pitching staff, but the Astros’ offense should give them the edge. Our pick: Astros to win.

8. San Francisco Giants vs. Miami Marlins
The Giants are slight favorites in this game, with odds of -110. The Marlins have a young and talented team, but the Giants’ experience should give them the edge. Our pick: Giants to win.

9. Los Angeles Dodgers vs. Colorado Rockies
The Dodgers are heavy favorites in this game, with odds of -250. The Rockies are rebuilding and are not expected to be competitive this season. Our pick: Dodgers to win.

10. Arizona Diamondbacks vs. San Diego Padres
The Padres are favored in this game, with odds of -180. The Diamondbacks have a solid lineup, but the Padres’ pitching staff should give them the edge. Our pick: Padres to win.

11. St. Louis Cardinals vs. Pittsburgh Pirates
The Cardinals are favored in this game, with odds of -170. The Pirates are rebuilding and are not expected to be competitive this season. Our pick: Cardinals to win.

12. Milwaukee Brewers vs. Chicago Cubs
The Brewers are favored in this game, with odds of -140. The Cubs have a young and talented team, but the Brewers’ pitching staff should give them the edge. Our pick: Brewers to win.

13. Philadelphia Phillies vs. Atlanta Braves
The Braves are favored in this game, with odds of -130. The Phillies have a solid lineup, but the Braves’ experience should give them the edge. Our pick: Braves to win.

14. New York Mets vs. Washington Nationals
The Mets are favored in this game, with odds of -150. The Nationals have a strong pitching staff, but the Mets’ offense should give them the edge. Our pick: Mets to win.

In conclusion, Opening Day is sure to be an exciting day for baseball fans and bettors alike. With 14 games on the schedule, there are plenty of opportunities to make some money by placing bets on your favorite teams. Good luck and enjoy the start of the MLB season!