Ohio State vs Indiana: Expert Prediction and Updated Odds for Saturday, November 23rd

• No. 5 Indiana puts perfect 10-0 record on the line at No. 2 Ohio State
• Sharp money has driven the line down from Buckeyes -12.5 to -10.5
• Read below for our Ohio State vs Indiana prediction, latest odds and best bet

The college football world gets a treat this Saturday (November 23), when the surprise story of the season – the undefeated #5 Indiana Hoosiers (10-0) – visit the #2 Ohio State Buckeyes (9-1) at Ohio Stadium. Kickoff is set for 12:00 PM ET on FOX in what’s shaping up to be a massive Big Ten showdown with huge playoff implications.

Ohio State has a chance to add another statement win to their resume for the Playoff committee. Their only slip-up came in that wild 32-31 road loss to current #1 Oregon, but they bounced right back by taking down Penn State. Meanwhile, Indiana is writing a fairytale under first-year head coach Curt Cignetti.

The Hoosiers are doing something nobody’s seen before – starting 10-0 for the first time ever. They’ve also got a shot to snap a brutal 28-game losing streak to the Buckeyes that goes all the way back to ’91.

The betting line opened with Ohio State as 12.5-point home favorites and the over/under at 52.5. But the sharp money’s been all over Indiana, pushing the line down to Buckeyes -10.5 as of Friday. Here’s the kicker – while only 5% of bets are on the Hoosiers moneyline, they’re drawing 57% of the handle, meaning the big-money players see something they like.

Ohio State vs Indiana Prediction

Indiana’s playing with house money – nobody saw this coming. After a rough 4-8 showing last year, most folks had the Hoosiers near the Big Ten basement. But they’ve flipped the script behind Ohio transfer QB Kurtis Rourke (2,410 yards, 21 TDs) and a straight-up nasty defense, giving up just 14 points per game.

That defense is about to face its biggest test yet against a loaded Ohio State offense putting up 37.8 points per game and 7.2 yards every time they snap the ball. The Buckeyes are stacked with playmakers – RBs Quinshon Judkins and TreVeyon Henderson, plus WRs Jeremiah Smith and Emeka Egbuka.

But here’s the thing—their O-line is hurting badly after losing two starters for the year. Left tackle Josh Simmons and center Seth McLaughlin have both suffered season-ending injuries, leaving major holes up front.

I think back to the spring just a few weeks after joining OSU, Seth McLaughlin was so proud to be a Buckeye.

He said here he hopes “they can see I add to this team”

His addition? He was arguably the best center in the country. He was also one of the biggest leaders for OSU: pic.twitter.com/nAqHNIDVjQ

— Adam King (@AdamKing10TV) November 20, 2024

That’s where Indiana might have an edge. Their defensive front, led by JMU transfer Mikail Kamara (Big Ten-best 9.5 sacks), could make life tough for the Buckeyes. If they can get after QB Will Howard and force some quick throws, watch out. The Hoosiers’ secondary, with ballhawks Jailin Walker and Amare Ferrell, knows how to capitalize on mistakes.

Sure, Ohio State’s defense leads the nation, allowing just 10.3 points per game. But they haven’t seen an offense quite like Indiana’s yet. Rourke’s been smart with the ball (21 TDs, only 4 picks), and if Justice Ellison and Ty Son Lawton can get the ground game going, the Hoosiers could keep the chains moving.

The home field edge matters, but there’s just too much pointing toward a closer game here – Indiana’s tough D, their explosive offense, Ohio State’s banged-up line, and all that sharp money coming in. Look for the Buckeyes to win around 31-23, but Indiana keeps it within the number.

• Pick: Indiana +10.5 (-110)

OSU vs Indiana Odds & Betting Lines

Here’s where things stand after all the line movement:

– Spread: Ohio State -10.5 (-110) | Indiana +10.5 (-110)
– Moneyline: Ohio State -380 | Indiana +300
– Total: Over 52.5 (-110) | Under 52.5 (-110)

That -380 on Ohio State means the books give them about an 80% chance to win outright. Indiana at +300? That’s a 25% shot at the upset. The Buckeyes are just 5-5 against the spread and a rough 1-6 in Big Ten games. Meanwhile, Indiana’s been money at 8-2 ATS, tied for best among Power 5 teams.

The total is stuck at 52.5, with even money both ways. These teams have been total opposites lately—Indiana has gone over in seven of ten games, while Ohio State has gone under in eight of ten. Something’s gotta give between the Buckeyes’ lockdown D and the Hoosiers’ high-powered offense.

Odds as of November 23, 2024, at Bet365 Sportsbook. Claim the Bet365 promo code to bet on Ohio State-Indiana.

Ohio State vs Indiana Betting Trends & Head-to-Head History

Let’s be real – Ohio State’s owned this matchup. They’ve won 30 straight against Indiana since ’88, going 79-12-5 all-time. The Buckeyes haven’t dropped a home game to the Hoosiers since ’91.

Last year’s meeting? Not pretty. Ohio State cruised 23-3 in Bloomington as 19-point favorites, holding Indiana to just 232 yards. Before that, the Buckeyes had been putting up 40+ points like clockwork, winning by an average of 36 points over seven games.

Indiana’s last top-5 win came against #4 Michigan back in ’87, and they’re just 3-9 ATS against ranked teams since 2021. But this isn’t your typical Hoosiers squad – especially on D. Plus, they’re coming off a bye while Ohio State had to hit the road last week.

Ohio State vs Indiana Recent Head-to-Head Results

Bottom line? The spread feels a bit rich for my liking. Ohio State’s offensive line issues and Indiana’s fierce pass rush could keep this one tighter than most expect. Roll with the Hoosiers and the points in what should be a four-quarter battle.

The Ohio State Buckeyes are set to face off against the Indiana Hoosiers in a highly anticipated college football matchup on Saturday, November 23rd. Both teams are coming off strong performances in recent weeks, making this game one to watch for fans of both schools.

The Buckeyes, currently ranked number two in the nation, have been dominant all season with a perfect 10-0 record. Led by star quarterback Justin Fields and a stout defense, Ohio State has been blowing out opponents week after week. Their high-powered offense, averaging over 50 points per game, will be a tough challenge for the Hoosiers to contain.

On the other side, the Hoosiers have had a solid season themselves, sitting at 7-3 and looking to pull off a major upset against the Buckeyes. Indiana’s offense has been clicking behind quarterback Peyton Ramsey, who has thrown for over 2,000 yards and 13 touchdowns this season. Their defense will need to step up big time against Ohio State’s potent attack if they hope to pull off the upset.

As for the odds, Ohio State is currently favored by double digits in this matchup. The Buckeyes are seen as heavy favorites to come out on top, but anything can happen in college football. Indiana will need to play a near-perfect game and capitalize on any mistakes made by Ohio State if they want to pull off the upset.

In terms of expert predictions, most analysts are leaning towards Ohio State to win this game comfortably. The Buckeyes have been one of the most dominant teams in college football this season and are expected to continue their winning ways against Indiana. However, the Hoosiers have shown they can compete with top teams in the past and could make this game closer than some expect.

Overall, this Ohio State vs Indiana matchup is shaping up to be an exciting showdown between two talented teams. Fans can expect a high-scoring affair with plenty of fireworks on both sides of the ball. Whether you’re rooting for the Buckeyes or the Hoosiers, this game is sure to be one you won’t want to miss.