Week 4 NFL Odds: Spread, Total, and Moneyline for All 16 Games

• Sportsbooks have posted the NFL Week 4 odds, including the spread, moneyline, and total for all 16 games
• Week 4 features another Monday Night Football doubleheader (Titans vs Dolphins, and Seahawks vs Lions)
• Below, see the opening NFL Week 4 odds for all games on the schedule

With Sunday Night Football and a pair of Monday night games still to go in Week 3, odds have already been released for all 16 NFL Week 4 games, which includes a second straight MNF doubleheader.

Week 4 opens with an NFC East battle between the Dallas Cowboys and New York Giants on Thursday Night Football before a 13-game slate on Sunday. It culminates with the Tennessee Titans vs Miami Dolphins and Seattle Seahawks vs Detroit Lions on Monday night.

The table below lists the opening Week 4 NFL odds for all 16 games on the schedule.

Opening NFL Week 4 Odds

Week 4 is another week of miniscule spreads. Eight of the 16 games have a point spread of 2.5 or lower.

Odds as of Sep. 22 at FanDuel, DraftKings, and ESPN Bet. Claim the top Week 4 NFL promos from the best sports betting sites. 

Biggest NFL Week 4 Point Spread: Chargers vs Chiefs (-10.5)

The biggest spread of Week 4 is in Kansas City where the Chiefs are 10.5-point home favorites over the Los Angles Chargers. While the two-time defending Super Bowl-champion Chiefs are going to be sizable favorites against most teams, this massive spread – indeed the biggest of the 2024 NFL season to date – is largely motivated by injuries on the other side. LAC’s 20-10 Week 3 setback to the Steelers dealt the Chargers multiple blows.

Not only was it their first loss of the season, but starting QB Justin Herbert and star edge rusher Joey Bosa both left with injury. Herbert was seen in a walking boot after the game and this spread indicates he won’t be in the lineup in Week 4.

Joe Mixon last week.
Justin Herbert this week.

I don’t understand why teams let these guys try to play through high ankle sprains. Risk of making it worse.

Looks like Herbert aggravated his left high ankle and limped off.
pic.twitter.com/E71IsvlolR

— Jeff Mueller, PT, DPT (@jmthrivept) September 22, 2024

KC is 2-0 with a Sunday Night Football tilt against the Atlanta Falcons still to do in Week 3.

Highest NFL Week 4 Game Total: Seahawks vs Lions (48.5)

The highest total of Week 4, by two full points, is in the Monday Night Football game between the Seattle Seahawks and Detroit Lions, which has a total of 48.5.

Oddsmakers still see the Lions as a high-octane offense paired with a sub-par defense, but the early returns in 2024 show a different dynamic. After going an NFL-best 14-6 O/U last year, the Lions are just 1-2 O/U after three weeks in 2024. Detroit games have averaged just 38.3 PPG. But even with their offense starting slowly, the Lions remain the +1200 fourth-favorite in the Super Bowl odds.

The 3-0 Seahawks haven’t been averaging much more – 38.6 PPG – and that includes an OT field goal in their Week 2 win at New England.

Lowest Week 4 Game Total: Titans vs Dolphins (37.5)

At the opposite end of the spectrum is the Titans vs Dolphins battle, which will precede Seahawks vs Lions in another MNF doubleheader. The Titans/Phins game total is just 37.5.

With Skylar Thompson playing in place of injured starter Tua Tagovailoa, Miami’s offense was held to just a field goal in a 24-3 loss at Seattle in Week 3. The Titans were routed 30-14 at home by Green Bay with Will Levis tossing two interceptions including a killer pick-six.

Tennessee has yet to score more than 17 points this season while the Dolphins have only managed 13 in the last eight quarters.

Keep tabs on the NFL public betting percentages to see where the money is going and how the Week 4 odds shifts between now and Sunday.

As we head into Week 4 of the NFL season, there are some exciting matchups on the schedule that are sure to have fans on the edge of their seats. With each team looking to secure a win and improve their standing in the league, the stakes are high for every game.

Let’s take a look at the odds for all 16 games in Week 4, including the spread, total, and moneyline for each matchup.

Thursday Night Football kicks off with the Jacksonville Jaguars taking on the Cincinnati Bengals. The Bengals are favored to win with a spread of -7.5 and a total of 45.5 points. The moneyline for this game has the Bengals at -320 and the Jaguars at +260.

On Sunday, the early games include the Washington Football Team facing off against the Atlanta Falcons. Washington is favored with a spread of -1.5 and a total of 48 points. The moneyline has Washington at -120 and Atlanta at +100.

In another early game, the Buffalo Bills will take on the Houston Texans. The Bills are heavily favored with a spread of -16.5 and a total of 47.5 points. The moneyline has the Bills at -2000 and the Texans at +1000.

In the late afternoon games, the Los Angeles Rams will play the Arizona Cardinals. The Rams are favored with a spread of -4 and a total of 54 points. The moneyline has the Rams at -210 and the Cardinals at +175.

The Sunday Night Football matchup features the Tampa Bay Buccaneers against the New England Patriots. The Buccaneers are favored with a spread of -6.5 and a total of 49 points. The moneyline has the Buccaneers at -275 and the Patriots at +225.

Finally, Monday Night Football will see the Las Vegas Raiders take on the Los Angeles Chargers. The Chargers are favored with a spread of -3 and a total of 52 points. The moneyline has the Chargers at -160 and the Raiders at +140.

These are just a few of the exciting matchups that will take place in Week 4 of the NFL season. With so much on the line for each team, it’s sure to be a thrilling weekend of football action. Be sure to keep an eye on the odds and place your bets accordingly as you cheer on your favorite teams to victory.